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Category: Research

Published: 15 December 2025

Research at Pars Medicine

Pars Medicine is committed to advancing medical knowledge through innovative, impactful research that improves human health. Our comprehensive research enterprise spans basic biomedical sciences, clinical investigation, translational medicine, population health, and health services research. With state-of-the-art facilities, robust funding support, and a collaborative culture, we provide an exceptional environment for discovery and innovation.

Research Mission and Vision

Our research mission is to generate new knowledge that transforms healthcare and improves lives. We pursue excellence in three interconnected domains:

• Discovery Science - Understanding fundamental biological mechanisms of health and disease through basic research
• Clinical Innovation - Developing and testing new diagnostics, therapeutics, and interventions through clinical trials
• Implementation and Impact - Translating discoveries into clinical practice and public health policy to benefit patients and communities

Research Infrastructure and Facilities

Pars Medicine maintains world-class research infrastructure supporting diverse scientific inquiry:

Core Research Facilities

• Molecular Biology Core - Next-generation sequencing, genomics, proteomics, and bioinformatics
• Flow Cytometry and Cell Sorting Facility - Multi-parameter analysis and cell isolation
• Imaging Core - Confocal microscopy, electron microscopy, live-cell imaging, and in vivo imaging
• Biorepository - Human tissue and biospecimen banking with rigorous quality control
• Animal Research Facility - AAALAC-accredited vivarium supporting rodent and large animal studies
• Biostatistics and Data Science Core - Statistical consultation, data management, and computational support
• Clinical Trials Unit - Dedicated space and infrastructure for clinical research studies
• Good Manufacturing Practice (GMP) Facility - Production of investigational agents for clinical trials

Specialized Research Centers

• Center for Cancer Research
• Cardiovascular Research Institute
• Neuroscience Research Center
• Infectious Disease and Immunology Institute
• Center for Metabolic and Endocrine Health
• Maternal and Child Health Research Program
• Center for Health Equity and Social Justice
• Institute for Regenerative Medicine and Stem Cell Biology

Research Focus Areas

Our faculty investigators lead research programs addressing major health challenges:

Cancer Biology and Therapeutics

Investigating molecular drivers of cancer, developing novel targeted therapies, immunotherapies, and precision medicine approaches. Major focus areas include breast cancer, lung cancer, hematologic malignancies, and pediatric cancers.

Cardiovascular and Metabolic Diseases

Studying mechanisms of heart failure, atherosclerosis, arrhythmias, diabetes, and obesity. Developing interventions ranging from pharmacologic agents to medical devices and lifestyle interventions.

Neuroscience and Neurological Disorders

Exploring brain development, neural circuits, neurodegeneration, stroke, traumatic brain injury, and mental health disorders. Integrating basic neuroscience with clinical neurology and psychiatry.

Infectious Diseases and Global Health

Investigating emerging infectious diseases, antimicrobial resistance, vaccine development, and implementation of evidence-based interventions in resource-limited settings.

Immunology and Autoimmune Diseases

Understanding immune system function, autoimmunity, transplant immunology, and immunodeficiency. Developing immunomodulatory therapies for diverse conditions.

Precision Medicine and Genomics

Leveraging genomic technologies to understand disease mechanisms, identify biomarkers, and develop personalized treatment strategies based on individual genetic profiles.

Population Health and Health Services

Studying healthcare delivery, health disparities, implementation science, health economics, and interventions to improve population health outcomes and health equity.

Funding and Support

Pars Medicine researchers secure competitive funding from diverse sources:

• Federal Agencies - NIH, NSF, CDC, AHRQ, DoD, VA
• Private Foundations - American Heart Association, American Cancer Society, Gates Foundation, Robert Wood Johnson Foundation
• Industry Partnerships - Pharmaceutical, biotechnology, and medical device companies
• Internal Funding - Pilot grants, career development awards, and research infrastructure support

Our Office of Research Administration provides comprehensive support including grant writing assistance, regulatory compliance, contract negotiation, financial management, and post-award administration.

Training and Education

We are committed to training the next generation of biomedical scientists through:

• PhD Programs - Biomedical sciences, public health, and health services research doctoral programs
• MD/PhD Program - Physician-scientist training combining medical and research education
• Postdoctoral Fellowships - Research fellowships across diverse scientific disciplines
• Clinical Research Fellowships - Advanced training for physician investigators
• Summer Research Programs - Undergraduate and medical student research opportunities
• Research Skills Workshops - Training in research methods, statistics, grant writing, and responsible conduct of research

Research Ethics and Integrity

All research at Pars Medicine adheres to the highest ethical standards. Our Institutional Review Board (IRB) oversees human subjects research, the Institutional Animal Care and Use Committee (IACUC) ensures humane animal research, and the Institutional Biosafety Committee (IBC) reviews biological safety protocols. We are committed to research integrity, transparency, and responsible conduct of research.

Research Collaboration

We actively collaborate with academic institutions, healthcare organizations, industry partners, community organizations, and government agencies worldwide. Our Office of Research Partnerships facilitates collaborations and technology transfer.

Recent Research Achievements

• Over 500 peer-reviewed publications annually in top-tier journals
• $150 million in annual research funding
• 15 FDA-approved therapies developed from institutional research
• Multiple patents and intellectual property licenses
• National and international research awards and recognition

For more information: Visit our Research Portal, contact the Office of Research at This email address is being protected from spambots. You need JavaScript enabled to view it., or call 555-0200 to explore research opportunities, resources, and collaborations.

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Category: Research

Published: 12 January 2026

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Category: Research

Published: 12 January 2026

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Category: Research

Published: 12 January 2026

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Category: Research

Published: 25 December 2025

At Pars University, research is central to our mission. Students at all levels have opportunities to engage in meaningful research that advances healthcare knowledge and improves patient outcomes.

Student Research Programs

Research Focus Areas

• Cancer Biology and Therapeutics
• Cardiovascular Disease
• Infectious Diseases
• Neuroscience and Neurodegeneration
• Healthcare Disparities
• Implementation Science
• Digital Health and AI
• Global Health
• Clinical Trials
• Health Policy Research

Research Resources

• Core Facilities: Flow cytometry, genomics, imaging, biostatistics
• Grant Support: Office of Sponsored Programs assists with applications
• IRB Services: Streamlined human subjects research approval
• Biobank: Access to de-identified specimens for approved research

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Category: Research

Published: 15 December 2025

Active Clinical Trials

We conduct over 200 active clinical trials spanning all phases (Phase I-IV) across multiple therapeutic areas. Here are some of our featured studies:

How to Participate

Participating in a clinical trial may provide access to promising new treatments while contributing to medical research. Follow these steps to get started:

We are committed to diversity, equity, and inclusion in clinical research. We actively recruit participants from diverse backgrounds and provide language assistance, transportation support, and flexible scheduling to reduce barriers to participation.

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Category: Research

Published: 15 December 2025

Basic Research Programs

Basic research at Pars Medicine explores fundamental mechanisms of biology, disease, and health to generate new knowledge that forms the foundation for future medical breakthroughs. Our basic scientists investigate questions at the molecular, cellular, and systems levels, using cutting-edge technologies to understand how biological processes work in health and go awry in disease.

Mission and Approach

Our basic research mission is to uncover fundamental biological principles that will ultimately transform medical care. We pursue curiosity-driven research asking: How do cells communicate? What makes cancer cells grow uncontrollably? How does the brain process information? What determines the balance between health and disease? These fundamental questions generate insights that lead to new diagnostics, therapeutics, and preventive strategies.

We embrace an interdisciplinary approach, bringing together expertise from molecular biology, biochemistry, genetics, immunology, neuroscience, pharmacology, and computational biology. Our researchers collaborate across traditional disciplinary boundaries, applying diverse methodologies to complex biological questions.

Research Focus Areas

Cancer Biology

Understanding the molecular and cellular mechanisms driving cancer initiation, progression, metastasis, and therapeutic resistance. Research areas include:

• Oncogenic signaling pathways and tumor suppressor mechanisms
• Cancer stem cells and tumor heterogeneity
• Tumor microenvironment and cancer-immune system interactions
• DNA damage response and genomic instability
• Epigenetic alterations in cancer
• Metabolism in cancer cells
• Mechanisms of metastasis and cancer dormancy

Immunology and Host Defense

Investigating how the immune system protects against infection and cancer while maintaining tolerance to self. Key research areas include:

• Innate and adaptive immune responses
• T cell and B cell biology
• Immune tolerance and autoimmunity
• Immunometabolism and immune cell function
• Mucosal immunity and microbiome interactions
• Vaccine development and immune memory
• Inflammatory pathways and resolution of inflammation

Neuroscience

Exploring brain structure, function, development, and disease at multiple scales from molecules to neural circuits. Research encompasses:

• Neural development and brain plasticity
• Synaptic transmission and neural circuits
• Neurodegeneration and protein aggregation
• Neuroinflammation and neuroimmunology
• Neurotransmitter systems and signaling
• Learning, memory, and cognitive function
• Neural stem cells and regeneration

Cardiovascular Biology

Understanding heart and blood vessel function in health and disease. Areas of investigation include:

• Cardiac development and congenital heart defects
• Cardiac electrophysiology and arrhythmia mechanisms
• Heart failure and cardiac remodeling
• Atherosclerosis and vascular biology
• Angiogenesis and vascular development
• Cardiac metabolism and energetics
• Cardiomyocyte biology and regeneration

Metabolic and Endocrine Disorders

Studying metabolic regulation and endocrine function. Research focuses on:

• Insulin signaling and glucose metabolism
• Adipocyte biology and obesity
• Mitochondrial function and metabolic disease
• Lipid metabolism and dyslipidemia
• Hormonal regulation of metabolism
• Energy balance and appetite control
• Metabolic liver disease

Genetics and Genomics

Leveraging genomic technologies to understand genetic contributions to health and disease:

• Gene regulation and transcriptional control
• Chromatin structure and epigenetic modifications
• Non-coding RNA function
• Genetic variation and disease susceptibility
• Genome editing and CRISPR technologies
• Single-cell genomics and cellular heterogeneity
• Computational genomics and bioinformatics

Infectious Disease and Microbiology

Investigating host-pathogen interactions and microbial pathogenesis:

• Viral replication and immune evasion
• Bacterial pathogenesis and antimicrobial resistance
• Host innate immune responses to infection
• Microbiome composition and host-microbe interactions
• Emerging infectious diseases
• Fungal and parasitic infections

Stem Cell Biology and Regenerative Medicine

Exploring stem cell properties and regenerative potential:

• Embryonic and adult stem cell biology
• Induced pluripotent stem cells (iPSCs)
• Tissue regeneration and repair mechanisms
• Organoid development and disease modeling
• Stem cell differentiation and fate determination
• Tissue engineering approaches

Research Laboratories and Principal Investigators

Our basic research programs are led by over 80 principal investigators directing independent research laboratories. Each lab focuses on specific research questions while contributing to broader departmental and institutional research themes. Faculty investigators hold positions in departments including:

• Department of Biochemistry and Molecular Biology
• Department of Microbiology and Immunology
• Department of Neuroscience
• Department of Pharmacology
• Department of Physiology
• Department of Cell and Developmental Biology
• Department of Genetics and Genome Sciences

Core Facilities and Technologies

Basic researchers have access to state-of-the-art core facilities providing advanced technologies:

• Genomics Core - Next-generation sequencing, RNA-seq, ChIP-seq, ATAC-seq, single-cell sequencing
• Proteomics and Mass Spectrometry - Protein identification, post-translational modifications, metabolomics
• Flow Cytometry - Multi-parameter cell analysis and cell sorting
• Imaging Core - Confocal, two-photon, electron microscopy, live-cell imaging
• Bioinformatics - Computational analysis, data visualization, algorithm development
• Transgenic and Genome Editing - CRISPR/Cas9, mouse models, viral vectors
• Structural Biology - X-ray crystallography, cryo-EM, NMR spectroscopy

Publications and Impact

Basic research at Pars Medicine generates high-impact discoveries published in leading scientific journals including Nature, Science, Cell, and specialized journals across disciplines. Our faculty publish over 400 research articles annually, advancing knowledge across biomedical sciences.

Recent notable discoveries include:

• Identification of novel molecular pathways regulating cancer metastasis
• Development of new CRISPR-based gene editing tools
• Discovery of immune checkpoint molecules with therapeutic potential
• Elucidation of neural circuits underlying memory formation
• Characterization of metabolic pathways in cardiovascular disease

Training and Education

Basic research laboratories provide exceptional training environments for graduate students, postdoctoral fellows, and undergraduate researchers. Training programs include:

• PhD Programs - Biomedical Sciences graduate program with diverse specializations
• MD/PhD Program - Combined physician-scientist training
• Postdoctoral Fellowships - Advanced research training across disciplines
• Summer Research Programs - Undergraduate research experiences
• Research Rotations - Laboratory exposure for medical and graduate students

Funding Support

Basic research programs are supported by competitive funding from NIH, NSF, American Heart Association, American Cancer Society, private foundations, and institutional resources. Our Office of Research provides grant writing support, regulatory guidance, and research administration.

Collaboration and Resources

We foster collaborative research through:

• Departmental and interdisciplinary seminar series
• Research symposia and retreats
• Shared core facilities and equipment
• Pilot grant programs for collaborative projects
• Partnerships with other academic institutions and industry

For more information: Explore our Faculty Research Directory, contact the Office of Basic Research at This email address is being protected from spambots. You need JavaScript enabled to view it., or call 555-0275 for information about research opportunities, collaborations, or training programs.

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Category: Research

Published: 15 December 2025

Translational Research

Translational research is the vital bridge connecting laboratory discoveries to clinical practice and public health impact. At Pars Medicine, our translational research programs accelerate the journey from bench to bedside and back again, ensuring that scientific breakthroughs improve patient care and that clinical observations generate new research questions. We are committed to translating knowledge into action to benefit patients and communities.

The Translational Research Vision

Translational research encompasses the full spectrum from basic discovery through clinical implementation and population health impact. We conceptualize translation as a bidirectional, iterative process:

• T0 Research - Basic biomedical research generating foundational knowledge
• T1 Translation - Moving discoveries from laboratory to human clinical trials
• T2 Translation - Establishing efficacy and effectiveness of interventions in clinical practice
• T3 Translation - Implementing evidence-based interventions in communities and health systems
• T4 Translation - Evaluating population health impact and informing policy

This comprehensive approach ensures that discoveries reach patients efficiently while clinical insights inform future research.

Translational Research Programs

Drug Discovery and Development

Our drug development pipeline spans target identification through clinical trials:

• Target Discovery and Validation - Identifying disease-relevant molecular targets using genomics, proteomics, and functional studies
• Hit-to-Lead Optimization - Screening compound libraries, optimizing drug-like properties, and medicinal chemistry
• Preclinical Development - Testing pharmacokinetics, toxicology, efficacy in animal models, and formulation
• IND-Enabling Studies - GMP manufacturing, regulatory preparation, and Investigational New Drug applications
• Clinical Trials - Phase I-III trials evaluating safety, dosing, efficacy, and comparative effectiveness

Recent drug development successes include novel targeted therapies for cancer, cardiovascular disease treatments, and antimicrobial agents now in clinical trials.

Biomarker Discovery and Validation

Identifying and validating biomarkers for disease diagnosis, prognosis, treatment selection, and monitoring:

• Multi-omics approaches (genomics, proteomics, metabolomics) for biomarker discovery
• Development of diagnostic assays and companion diagnostics
• Clinical validation studies establishing biomarker utility
• Integration of biomarkers into clinical decision-making
• Liquid biopsy development for non-invasive disease monitoring

Medical Device and Technology Development

Translating engineering innovations into clinical applications:

• Diagnostic devices and point-of-care testing platforms
• Implantable devices (cardiac devices, neural implants, drug delivery systems)
• Wearable sensors and remote monitoring technologies
• Surgical instruments and minimally invasive technologies
• Digital health tools and mobile health applications
• Artificial intelligence and machine learning for clinical decision support

Cell and Gene Therapy

Developing advanced cellular and genetic therapies:

• CAR-T cell therapy for cancer and autoimmune diseases
• Gene therapy vectors and delivery systems
• Genome editing approaches (CRISPR/Cas9, base editing, prime editing)
• Stem cell therapies for regenerative medicine
• Manufacturing and quality control for cell-based therapies
• Clinical trials evaluating safety and efficacy

Precision Medicine and Pharmacogenomics

Personalizing treatment based on individual patient characteristics:

• Genomic profiling to guide cancer therapy selection
• Pharmacogenomic testing for drug dosing and selection
• Integration of multi-omic data for treatment decisions
• Clinical implementation of precision medicine approaches
• Health equity in precision medicine

Imaging and Diagnostic Technologies

Advancing diagnostic imaging capabilities:

• Novel imaging probes and contrast agents
• Advanced MRI, PET, and CT imaging techniques
• Molecular imaging for early disease detection
• Image-guided therapies and interventions
• Artificial intelligence for image analysis and interpretation

Infrastructure and Resources

Pars Medicine provides comprehensive infrastructure supporting translational research:

Translational Research Centers

• Center for Drug Discovery and Development - High-throughput screening, medicinal chemistry, pharmacology
• Institute for Precision Medicine - Genomic medicine, bioinformatics, precision diagnostics
• Cell and Gene Therapy Center - GMP manufacturing, vector production, clinical cell therapy
• Biomarker Development Laboratory - Biomarker discovery, assay development, clinical validation
• Medical Device Innovation Center - Prototyping, testing, regulatory support for device development

Core Facilities

• GMP manufacturing facility for investigational products
• Biorepository with clinical specimens linked to outcomes data
• Phase I Clinical Research Unit for early-stage trials
• Genomics and proteomics cores
• Preclinical imaging facility
• Bioinformatics and computational biology resources

Regulatory and Administrative Support

• Office of Regulatory Affairs providing FDA/IND support
• Clinical Trials Office for study design and implementation
• Technology Transfer Office for patents, licensing, and commercialization
• IRB and IACUC for ethical oversight
• Quality assurance and regulatory compliance support

Partnerships and Collaboration

Successful translation requires diverse partnerships:

Academic Collaborations

Multi-institutional collaborations leveraging complementary expertise, sharing resources, and conducting multi-center trials.

Industry Partnerships

Collaborations with pharmaceutical, biotechnology, and medical device companies for co-development, licensing, and clinical trials. Partnerships accelerate translation while supporting institutional research.

Clinical Practice Integration

Embedded translational research within clinical care settings, enabling rapid clinical testing and implementation while ensuring patient access to innovations.

Community Engagement

Partnership with patient advocacy groups, community organizations, and patients to ensure research addresses real-world needs and benefits diverse populations.

Recent Translational Achievements

• First-in-human trials of novel cancer immunotherapy developed in institutional laboratories
• FDA approval of diagnostic biomarker test for cardiovascular disease risk
• Implementation of pharmacogenomic testing into routine clinical care
• Development of wearable device for continuous glucose monitoring
• CAR-T cell therapy trials for refractory hematologic malignancies
• Gene therapy trials for inherited retinal diseases
• AI-based diagnostic tool for early detection of sepsis

Training and Education

We train the next generation of translational scientists through:

• Translational Science Training Programs - Interdisciplinary training in translational research methods
• KL2 Career Development Awards - Mentored career development for junior translational investigators
• Clinical Research Training - Programs for clinician-scientists conducting translational studies
• Regulatory Science Education - Training in FDA processes, GCP, and regulatory requirements
• Entrepreneurship Programs - Supporting commercialization and startup development

Funding and Support

Translational research programs are supported by:

• NIH Clinical and Translational Science Awards (CTSA)
• Disease-focused foundations and advocacy organizations
• Industry-sponsored research agreements
• Institutional pilot grants and gap funding
• Venture capital and angel investment for startups

Impact Metrics

Our translational research enterprise generates measurable impact:

• 15-20 IND applications filed annually
• 50+ active early-phase clinical trials
• 100+ patents issued over past five years
• 25+ technology licenses executed
• Multiple FDA-approved therapies originating from institutional research
• Startup companies launched based on discoveries

For more information: Contact the Office of Translational Research at This email address is being protected from spambots. You need JavaScript enabled to view it., call 555-0300, or visit the Translational Research Resources Portal for information about programs, funding, facilities, and collaboration opportunities.